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Learn About PSSM

Learn About PSSM

Learn About PSSM

Real Life PSSM Stories
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EXPERIMENTAL

IAR is Impaired Acrosomal Reaction - genetic inheritance is still under investigation

This gene impairs fertility - studies so far have only been carried out on males - IAR horses can reproduce but very erratically. .

 

There are two mutaions 

Etalon is testing for this on an experimental basis - if you have a horse with fertility issues contact them and see if you can be involved in their research project.

 

Test Results look like this:

 /-, -/+   One    IAR Subfertility allele detected - NO KNOWN EFFECT
-
/+, -/+  Two    IAR Subfertiliy alleles detected - NO KNOWN EFFECT
+/+, +/- Three IAR Subfertility alleles detected - NO KNOWN EFFECT
+/+, +/+ Four  IAR Subfertility alleles detected - MAY BE AFFECTED

 

                                                                

 

 

 

 

 

 

 

 

 

*This study/allele set has only been conducted in Thoroughbred horses, the effects are yet unknown in other breeds.  If you suspect your horse/stallion has fertility issues (validated by veterinarian or the inability to settle multiple mares) please contact us and participate in the ongoing research project.

 

 

 

WFFS stands for Warmblood Fragile Foal Syndrome - it is a recessive disorder  Genetic Testing is Available


WFFS causes thin, fragile skin. Affected foals may be born with skin lesions and an open abdomen and are typically euthanized at birth or within a few days of birth. It is similar to HERDA except is shows up at birth.

There is no effective treatment. 

Warmblood Fragile Foal Syndrome is reported only in Warmbloods. 

There are a few different Labs that test for it - enquire at your favorite lab.

GT is Thrombosenia - a recessive disorder

Thrombasthenia is a bleeding disorder where the horses blood doesn't clot properly, these horses bleed excessively. 
Symptoms include weakness in the hind end, trouble getting up, cold limbs, low pulse

There is no effective treatment.

It is found in Throughbreds.

Genetic Codes for GT:

N/N Normal Cannot produce an affected foal

N/gt1 Horse is a carrier of GT, and can passto to approximately 50% of any offspring. If bred to another N/gt1 carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.

N/gt2 Horse is a carrier of GT, and can pass the allele on to approximately 50% of any offspring. If bred to another N/gt2 carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.

gt1/gt1 The horse is affected with GT. If bred to a normal animal, 100% of the offspring will be carriers. If bred to a N/gt1 carrier, 50% of the offspring will be carriers and 50% will be affected.

gt2/gt2 The horse is affected with GT. If bred to a normal animal, 100% of the offspring will be carriers. If bred to a N/gt2 carrier, 50% of the offspring will be carriers and 50% will be affected.

gt1/gt2 The horse is affected with GT. If bred to a normal animal, 100% of the offspring will be carriers. If bred to a N/gt1 or N/gt2 carrier, 50% of the offspring will be carriers and 50% will be affected.

Recommendations:
– Carriers may be bred to normal animals (N/gt1/gt2 x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/gt1/gt2 x N/gt1/gt2) is not recommended due to the possibility of 25% of the offspring being affected.

SWO stands for Splashed White Overo - it is a recessive disorder

SWO is another coat pattern defect - it applies to patterns that determine white.  Embryos that receive two of these genes will not complete development and will abort in the womb.

Hearing loss is associated with White Patterned horses - horses white on the inside of the ear are affected - horses who's ears have pigmented hair inside the ear are not affected.

Splashed White 2 (SW2) and Splashed White 3 (SW3) are found Quarter Horses and related breeds.

Genetic Codes:

SW1/SW1 Homozygous Horse has two copies of the SW-1 mutation
N/SW1 Heterozygous Horse has one copy of the SW-1 mutation
N/N Negative No copies of SW-1 mutation
SW2/SW2 Homozygous Horse has two copies of the SW-2 mutation
N/SW2 Heterozygous Horse has one copy of the SW-2 mutation
N/N Negative No copies of SW-2 mutation
SW3/SW3 Homozygous Possible homozygous lethal
N/SW3 Heterozygous Horse has one copy of the SW-3 mutation
N/N Negative No copies of SW-3 mutation
SW4/SW4 Homozygous Possible homozygous lethal but no current information available
N/SW4 Heterozygous Horse has one copy of the SW-4 mutation
N/N Negative No copies of SW-4 mutation

ODSD means Ovotesticular Disorder of Sexual Development it is a dominant mutation


ODSD produces sterile females - it only comes from the stallion - all foals born are either normal colts or fillys that cannot have foals of their own.

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Fun Facts

Stats

May 21, 2019

Horses 278,224

5 Panel NN 4558

PSSM1 nn 8813
PSSM1 pos 3047
PSSM2 pos 766

HYPP nn 9317
HYPP pos 4866

 

 

 

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FUN FACTS